Table 2.
Effects of Pre-Treated MSCs Combined With Other Cell Types and Drugs.
| Pre-treatment | Type | Response | Specific effect | Year |
|---|---|---|---|---|
| Rapamycin86 | BMMSCs | Improved | Reverse aging phenotype of Lupus BMMSCs Improved immune regulation and increased the proportion of Treg/Th17 cells |
2016 |
| Ethyl pyruvate87 | BMMSCs | Improved | Reverse aging phenotype of BMMSCs Improved immune regulation of Treg |
2019 |
| Acetylsalicylic acid88 | Inflamed GMSCs | Improved | Restore the immunomodulatory properties of impaired inflamed GMSCs. Improve T cell apoptosis mediated by IGMSCs | 2019 |
| HCQ89 | hUC-MSCs | Improved | Enhance MSCs to improve renal morphology and function | 2018 |
| GDNF46 | ADSCs | Improved | Protective effect of GDNF modified ADSC on renal interstitial fibrosis was enhanced. | 2021 |
| Phorbol ester90 | BMMSCs | Improved | Activate mesenchymal stem cells to regulate B cells and improve lupus symptoms | 2020 |
| Metformin91 | ADSCs | Improved | Metformin enhanced STAT1 expression of ADSCs and enhanced its immunomodulatory effect | 2020 |
| Combination therapy | Type | Response | Specific effect | Year |
| Hematopoietic stem cells92 | Amnion-derived MSCs | Improved | Transfusion-related graft-versus-host reaction is rare. Improve kidney function |
2021 |
| CsA93 | ADSCs | Improved | Reduce immunosuppressant dosage while maintaining or improving therapeutic effect | 2017 |
| Rapamycin93 | ADSCs | Improved | Promotes the function of anti-inflammatory Treg lymphocytes. | 2017 |
| MMF93 | ADSCs | Improved | Synergistic effect | 2017 |
| Glucocorticoids93 | ADSCs | Improved | Induced upregulation of Th17-related responses | 2017 |
| HCQ89 | hUC-MSCs | Ineffective | Less effective than HCQ and MSCs alone in mice | 2018 |
| IL-3794 | BMMSCs | Improved | To systemic lupus erythematosus additive therapeutic effect | 2020 |
ADSCs: adipose tissue–derived stem cells; BMMSCs: bone marrow–derived mesenchymal stromal cells; GDNF: glial cell line–derived neurotrophic factor; GMSCs: gingiva-derived mesenchymal stromal cells; HCQ: hydroxychloroquine; HSC: haematopoietic stem cell; MMF: mycophenolate mofetil; IGMSCs: inflammatory gingiva-derived mesenchymal stromal cells; MSC: mesenchymal stromal cell; hUC-MSC: human umbilical cord–derived mesenchymal stromal cell.