Table 6.
Example of an individual participant data meta-analysis reporting result of the risk-of-bias assessment for the included studies. Information adapted from information licensed under the Non-Commercial Government Licence version 2.0115
| Study/dataset | Domain: predictors | |||||
|---|---|---|---|---|---|---|
| Predictors defined in a similar way for participants | Predictors defined in a similar way to model development study | Predictors assessed without knowledge of outcome data | All predictors available at the time model is to be used | Risk | Rationale | |
| Allen | Yes | NA | Yes | Yes | Low | Responses all yes to signalling questions |
| ALSPAC | Yes | NA | Yes | Yes | Low | Responses all yes to signalling questions |
| Chappell | Probably no | NA | Probably yes | Yes | High | Historical data and definition of predictor may differ over time |
| EMPOWAR | Yes | NA | Yes | Yes | Low | Responses all yes to signalling questions |
| Poston 2006 | Yes | NA | Yes | Yes | Low | Responses all yes to signalling questions |
| Poston 2005 | Yes | NA | Yes | Yes | Low | Responses all yes to signalling questions |
| UK SCOPE | Yes | Yes | Yes | Yes | Low | Responses all yes to signalling questions |
| St Georges | Probably yes | NA | Probably yes | Yes | Low | Responses all yes to signalling questions |
| Velauthar | No information | NA | No information | Yes | Unclear | No information to make assessment |
Risk-of-bias assessment for predictors available in an individual participant data meta-analysis to develop and validate predictions models for pre-eclampsia. NA=not applicable; SCOPE=Screening for Pregnancy Endpoints; ALSPAC=Avon Longitudinal Study of Children and Parents; EMPOWAR=Efficacy of Metformin in Pregnant Obese Women (a randomised controlled trial).