Table 1:
Right entorhinal cortex volume versus cortical SUVR – correlations and structural equation modeling
| Correlations (Compound Deficits Cluster) | Structural equation modeling | ||||||
|---|---|---|---|---|---|---|---|
| Coefficient (rs) | p-Value 1 | High Performing 2 | Memory Deficits 2 | Compound Deficits 2 | |||
| Standardized uptake value ratio (SUVR, PET) | Whole cerebral | –0.437 | 0.006* | –0.030 (0.73) | 0.008 (0.94) | –0.412 (0.005) | |
| Total temporal | –0.394 | 0.014* | |||||
| Superior temporal | Left | –0.420 | 0.009* | –0.020 (0.73) | –0.025 (0.73) | –0.396 (0.008*) | |
| Right | –0.443 | 0.005* | –0.044 (0.49) | –0.047 (0.49) | –0.407 (0.006*) | ||
| Caudal middle frontal | Left | –0.355 | 0.029* | –0.090 (0.30) | –0.017 (0.86) | –0.475 (0.001**) | |
| Right | –0.345 | 0.034* | –0.088 (0.31) | –0.039 (0.70) | –0.437 (0.003*) | ||
| Rostral middle frontal | Left | –0.435 | 0.006* | –0.099 (0.25) | –0.019 (0.85) | –0.498 (<0.001**) | |
| Right | –0.411 | 0.010* | –0.116 (0.18) | –0.006 (0.95) | –0.495 (<0.001**) | ||
| Lateral orbitofrontal | Left | –0.285 | 0.08 | –0.049 (0.47) | –0.046 (0.47) | –0.377 (0.012*) | |
| Right | –0.285 | 0.08 | –0.061 (0.36) | –0.057 (0.36) | –0.406 (0.006*) | ||
| Medial orbitofrontal | Left | –0.381 | 0.018* | –0.007 (0.92) | –0.006 (0.92) | –0.421 (0.004*) | |
| Right | –0.381 | 0.018* | –0.007 (0.92) | –0.006 (0.92) | –0.421 (0.004*) | ||
| Superior frontal | Left | –0.348 | 0.032* | –0.046 (0.60) | –0.019 (0.85) | –0.458 (0.002**) | |
| Right | –0.333 | 0.041* | –0.056 (0.52) | –0.030 (0.76) | –0.435 (0.003*) | ||
| Precuneus | Left | 0.200 | 0.10 | –0.011 (0.87) | –0.011 (0.87) | –0.291 (0.06) | |
| Right | 0.155 | 0.20 | –0.026 (0.69) | –0.026 (0.69) | –0.316 (0.040*) | ||
| Supramarginal | Left | 0.067 | 0.58 | –0.031 (0.60) | –0.038 (0.60) | –0.400 (0.007*) | |
| Right | 0.050 | 0.68 | –0.052 (0.40) | –0.057 (0.40) | –0.509 (<0.001**) | ||
| Rostral anterior cingulate | Left | 0.128 | 0.29 | –0.013 (0.85) | –0.013 (0.85) | –0.421 (0.004*) | |
| Right | 0.109 | 0.37 | –0.025 (0.70) | –0.025 (0.70) | –0.387 (0.010*) | ||
| Caudal anterior cingulate | Left | 0.119 | 0.33 | –0.025 (0.69) | –0.027 (0.69) | –0.444 (0.002**) | |
| Right | 0.194 | 0.11 | –0.029 (0.66) | –0.030 (0.66) | –0.446 (0.002**) | ||
| Posterior cingulate | Left | 0.120 | 0.32 | –0.032 (0.60) | –0.037 (0.60) | –0.385 (0.010*) | |
| Right | 0.166 | 0.17 | –0.015 (0.81) | –0.017 (0.81) | –0.385 (0.010*) | ||
1
Correlations considered significant without correction (*) if <0.05; significant with Bonferroni correction (**) if <0.002.
2
Standard regression estimates calculated from structural equation modeling utilizing various cortical standardized uptake value ratios (with whole cerebellum as reference) and right entorhinal cortex volume as parameters. Values are given as coefficient (p-Value, significant without correction [*] if <0.05, with Bonferroni correction [**] if <0.002).