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. 2022 Dec 21;70(11-12):751–757. doi: 10.1369/00221554221145998

Figure 3.

Figure 3.

The hanging structure of COLVII and its co-localization with elastic fiber decrease with age. (A) Immunofluorescent three-dimensional images of COLVII and elastic fibers in the skin tissue from women in their 20s to 70s. Each picture depicts the merged images (above) and COLVII (below). The results indicate that the elongation of COLVII to the dermis decreases with age. Blue: nuclear; green: COLVII; red: tropoelastin. Scale bar = 10 µm. (B) The graphs represent the correlation analysis for age, elastin structure, co-localization region, and elastic fiber length. Each graph reveals the relationship between the extended structure of COLVII and age (left) and the co-localization region and age (right). Both elongation of COLVII to the dermis and co-localization with fibrous tropoelastin were found to decrease with aging.