Table 2.
Gene | CpG site | P-value | Q-value | Chr:pos | Coefficient | Beta diff.* | Relation to Island** |
---|---|---|---|---|---|---|---|
KDM1A | cg22225928 | 2.80E-07 | 0.08 | chr1:23358458 | 0.08 | 3% | Open Sea |
ZMIZ1 | cg20543544 | 3.67E-07 | 0.08 | chr10:81003657 | −0.24 | −5% | Island |
TERT | cg17166338 | 3.77E-07 | 0.08 | chr5:1295969 | 0.15 | 3% | Island |
SOX18 | cg01355392 | 5.66E-07 | 0.09 | chr20:62679255 | −0.13 | −6% | N. Shore |
Difference in average Methylation beta values between Cerro de Pasco and Lima
According to an annotation from Illumina
The model was adjusted for study group, sex, age, and blood principal components
WBLL = Whole blood lead levels