Table 3.
Significant differentially methylated regions (DMRs) associated with metal ion binding and neurological pathways.
| Gene | Region | Relation_to_Island* | N probes | P-value region | Corrected p-value | Δ Meth** | Relevant function*** |
|---|---|---|---|---|---|---|---|
| ZBTB16 | chr11:113933513–113935052 | S. Shore | 7 | 1.33E-08 | 5.65E-06 | ↑ | Metal ion binding |
| ZNF710 | chr15:90543224–90544600 | N. Shore | 6 | 1.63E-07 | 7.75E-05 | ↓ | Metal ion binding |
| ZNF292 | chr6:87861261–87862482 | N. Shore | 6 | 7.16E-07 | 0.000385 | ↓ | Metal ion binding |
| MEX3A | chr1:156046344–156046833 | Island | 4 | 2.05E-08 | 2.74E-05 | ↓ | Metal ion binding |
| DPP6 | chr7:153583318–153584874 | Island | 13 | 4.54E-06 | 0.001913 | ↑ | Neurodegeneration; metal ion binding; metal ion transport |
| HOXB3 | chr17:46647787–46653712 | Open Sea | 21 | 5.77E-14 | 6.39E-12 | ↓ | Neurogenesis |
| NNAT | chr20:36148133–36149751 | N. Shore | 38 | 2.01E-08 | 8.15E-06 | ↓ | Neurogenesis; neuron differentiation |
| PRMT1 | chr19:50190825–50191684 | N. Shore | 6 | 3.98E-07 | 0.000304 | ↓ | Neurogenesis; neuron differentiation |
| EPHA2 | chr1:16472001–16473144 | N. Shelf | 3 | 8.32E-07 | 0.000477 | ↓ | Neurogenesis; neuron differentiation |
| STRA6 | chr15:74495109–74496041 | OpenSea | 9 | 9.2E-06 | 0.006455 | ↓ | Neurological system process |
| ZNF385A | chr12:54763081–54764372 | Island | 6 | 5.25E-08 | 2.67E-05 | ↓ | Neurological system process; Metal ion binding |
| AGAP2 | chr12:58131681–58133184 | Island | 10 | 5.57E-10 | 2.43E-07 | ↓ | Neuron death; regulation of neuron apoptosis; Metal ion binding |
| SNAP23 | chr15:42800679–42800834 | Open Sea | 2 | 5.06E-06 | 0.02117 | ↑ | Neurotransmitter transport; regulation of neurotransmitter levels |
*
According to annotation from Illumina
**
Direction of association with WBLLs
***
According to functional annotation from DAVID