Table 1.
Effect of KEMCT treatment on isoflurane anesthesia-evoked changes in blood R-βHB and glucose levels
| Treatments | Glucose (mg/dl) | R-βHB (mmol/l) |
|---|---|---|
| Water gavage (3 g/kg) (Group 1; Fig. 1A and B) | ||
| Control (measured on the last day of the adaptation period) | 83.33 ± 2.867 | 0.79 ± 0.034 |
| After 7th gavage and isoflurane anesthesia (7thW and Isoflu) | 143.58 ± 4.177 | 1.08 ± 0.048 |
| Compared to Control (significance level/p value) | ****/ < 0.0001 | ***/0.0005 |
| KEMCT gavage (3 g/kg) (Group 2; Fig. 1C and D) | ||
| Control (measured on the last day of the adaptation period) | 85.58 ± 1.786 | 0.81 ± 0.023 |
| After 1st gavage | 62.83 ± 2.306 | 1.93 ± 0.182 |
| Compared to Control (significance level/p value) | ****/ < 0.0001 | **/ < 0.0033 |
| After 7th gavage and isoflurane anesthesia (7thK and Isolfu) | 90.75 ± 2.850 | 3.56 ± 0.339 |
| Compared to Control (significance level/p value) | ns/0.2805 | ****/ < 0.0001 |
Abbreviations: 7thK and Isolfu, 7th KEMCT gavage and isoflurane anesthesia; 7thW and Isoflu, 7th water gavage and isoflurane anesthesia; KEMCT (mix of ketone ester/KE and medium chain triglyceride/MCT oil in a 1:1 ratio); ns, non-significant
**p < 0.01
***p < 0.001
****p < 0.0001