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. 2023 Feb 7;23:125. doi: 10.1186/s12885-023-10596-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 12 — Construction of the ceRNA network and relationship between RRM2 expression and gliomas. A Schematic model of ceRNA (HELLPAR-hsa-let-7i-5p-RRM2). B Base pairing between hsa-let-7i-5p, HELLPAR and RRM2 were predicted by StarBase. C RRM2 expression levels in different tumor types from TCGA and GTEx database. D RRM2 mRNA expression was significantly upregulated in gliomas tissues compared to normal tissues. E Diagnostic value of RRM2 expression in gliomas. F RRM2 protein expression in gliomas tissues determined using HPA. ***p < 0.001, ns, no statistical difference