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. 2023 Feb 7;42:42. doi: 10.1186/s13046-023-02607-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — GPX8 is associated with higher grade and poor prognosis in ccRCC A, Two-tiered bioinformatic screening to find genes correlated with metabolites (top; CCLE database) and genes (bottom; TCGA-KIRC (Kidney renal clear cell carcinoma) database) of glycogen and lipid metabolism in ccRCC. The metabolites and genes used as queries are indicated in each Venn diagram. The criteria were set to FDR < 0.0001 and |r|< 0.15. The numbers in the Venn diagram represent the numbers of genes that meet the criteria. B-D, Violin plots for the mRNA expression levels of GPX8 according to (B) normal vs. tumor, (C) neoplasm histologic grade, and (D) alive or dead-tumor-free group vs. dead-with-tumor group among ccRCC patients. The mRNA expression values were obtained from the TCGA-KIRC dataset. P-values were determined by Mann–Whitney U test. E, Overall survival according to GPX8 mRNA expression for ccRCC patients from TCGA-KIRC database. F, GPX8 IHC staining for tumor array sections (KD482_biomax) from ccRCC patients. Magnification 400X