Figure 5.

Three classes of sSNVs at the branching point of two copy number states

Schematic representations of classes 1–3 on the top row. The two rows below show identified instances of each class. Each marker indicates a single cell. Its color and shape indicate whether the alternative allele (red, circle) or the reference allele (blue, square) is detected or the sSNV is not covered (gray, triangle).

(A) In class 1, the copy number aberration occurs after the sSNV appearance.

(B) In class 2, the copy number aberration occurs before the sSNV appearance.

(C) Class 3 is an example of a parallel evolution event, in which a sSNV is followed by two independent copy number aberrations.