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The effect of gene function on the landscape of rare-variant associations
The proportion of gene-annotation pairs with at least one association (SKAT-O p < 2.5 × 10−7) is shown for a number of gene categories, each compared with a background set of genes matched on CAF. Error bars represent 95% confidence intervals. Asterisks denote a significant difference between the background and test sets (∗p < 0.05 and ∗∗p < 0.001, respectively).
