Table 2.
UCLA ATLAS contributes a substantial proportion of non-European ancestry samples to global meta-analyses
| Trait | Abbreviation | Ancestry | UCLA case | GBMI case | Enrichment ratio |
|---|---|---|---|---|---|
| Asthma | asthma | EUR | 3,051 | 101,311 | 1.04 |
| AFR | 289 | 5,051 | 1.97 | ||
| AMR | 760 | 4,069 | 6.42 | ||
| EAS | 308 | 18,549 | 0.57 | ||
| Chronic obstructive pulmonary disease | COPD | EUR | 2,005 | 51,644 | 1.14 |
| AFR | 187 | 1,978 | 2.77 | ||
| AMR | 384 | 1,503 | 7.49 | ||
| EAS | 208 | 19,044 | 0.32 | ||
| Gout | gout | EUR | 810 | 20,702 | 1.16 |
| AFR | 105 | 1,312 | 2.38 | ||
| AMR | 179 | 557 | 9.55 | ||
| EAS | 155 | 10,425 | 0.44 | ||
| Heart failure | HF | EUR | 1,301 | 28,795 | 1.51 |
| AFR | 174 | 1,367 | 4.26 | ||
| AMR | 423 | 1,170 | 12.11 | ||
| EAS | 144 | 12,665 | 0.38 | ||
| Idiopathic pulmonary fibrosis | IPF | EUR | 700 | 5,229 | 1 |
| AFR | 76 | 169 | 3.37 | ||
| AMR | 204 | 319 | 4.79 | ||
| EAS | 89 | 1,210 | 0.55 | ||
| Cerebral artery occlusion with cerebral infarction | stroke | EUR | 855 | 15,842 | 2.48 |
| AFR | 100 | 1,161 | 3.96 | ||
| AMR | 248 | 903 | 12.64 | ||
| EAS | 105 | 23,345 | 0.21 | ||
| Venous thromboembolism | VTE | EUR | 1,503 | 15,970 | 1.11 |
| AFR | 195 | 1,466 | 1.57 | ||
| AMR | 543 | 1,037 | 6.18 | ||
| EAS | 132 | 193 | 8.07 |
We show the case sample sizes across 7 traits for ATLAS and across the entire GBMI study, stratified by genetic ancestry. The last column reports the ratio of the proportion of ancestry-specific samples in ATLAS compared with the proportion of total samples from the GBMI meta-analyses.