Figure 3.

ICD10 code case/control copy number associations

(A) Combined and overlaid Manhattan plot for CNV associations across 44 ICD10 codes.

(B) Combined QQ plot including all p values from association results across all 44 traits.

(C) Overlaid QQ plots showing all individual QQ plots for the 44 traits.

(D) Plot showing the total number of exons for all ICD10 codes that had any significant signal.

(E) Locus zoom plot at UGT1A genes for ICD10 code E80 (disorders of porphyrin and bilirubin metabolism).

(F) Locus zoom plot at the PRSS1 gene for ICD10 code D50 (iron deficiency anemia).

(G) Locus zoom plot at the SLC2A9 gene for ICD10 code M10 (gout).

(H) Locus zoom plot at the RHD and RHCE genes for ICD10 code O 36 (maternal care for known or suspected fetal problems).

(I) Locus zoom plot at the PNPLA3 gene for ICD10 code K74 (fibrosis and cirrhosis of liver).