Figure 3.

Consistency of loci across biobanks and asthma age-of-onset subtypes

(A) Regression slopes computed using the Deming regression method, which compared effects of index variants in each biobank GWAS against their effects in the corresponding leave-that-biobank-out meta-analysis.²³ The x axis shows the effective sample size of each biobank, computed as 4/(1/cases + 1/controls). Error bars represent 95% confidence intervals of the regression slope estimates.

(B) Effect sizes of the index variants discovered in the all-asthma meta-analysis as estimated in the COA versus AOA meta-analyses compared using the Deming regression method.³⁵ The intercept was set to be 0; the slope estimated from the regression analysis is reported. Error bars represent 95% confidence intervals of the effect size estimates from the corresponding meta-analysis.

See also Figures S4 and S5; Tables S5 and S11.