Figure 5.

PRS performance across ancestries

Each panel represents a target cohort in which PRS constructed using PRS-CSx and PRS-CS were evaluated. The reference dataset was the TAGC meta-analysis.⁵ Sample sizes for the target cohorts are: cases = 849 and controls = 5,190 for AFR; cases = 500 and controls = 500 for EAS; cases = 1,164 and controls = 7,577 for EUR; cases = 1,232 and controls = 6,744 for CSA. Error bars represent standard deviation of R² on the liability scale across 100 replicates. See also Figure S10; Tables S9 and S10.