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. 2022 Jun 8;2(6):100142. doi: 10.1016/j.xgen.2022.100142

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Trajectory analysis of cell subpopulations and characterization of pseudotime-related disease pathways

(A) Global lineages were constructed using proliferative subpopulation, RPC1 as the origin, and subpopulations RGC1, photoreceptors, interneurons, RPE, and lens as the endpoints. This resulted in a branching trajectory, with RGC subpopulations—RGC1, RGC2, RGC3, and their progenitors—RPC9 and RPC13, segmenting off the main trajectory at RPC11.

(B) The branching trajectory consists of 12 lineages. Three of these lineages, 6, 7, and 9, belong to the RGC subpopulations.

(C) Pathways associated with the RGC lineage over pseudotime.

(D) Relationship between genotype and expression profiles of HMGB1 at SNP rs9578147, in subpopulations RGC1, RGC2, RGC3, and RPE.