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. 2022 Nov 30;2(12):100219. doi: 10.1016/j.xgen.2022.100219

Figure 5.

Figure 5

Interpopulational and case-control comparisons of the crAss-like phages

(A) A maximum-likelihood phylogenetic tree reconstructed from the TerL proteins of the crAss-like phages. The color of the nodes represents the species-level clusters present only in the JVD (magenta), present only in the reference (green), or neither of the cases (navy). The outer rings represent the subfamily-level (inner) and genus-level (outer) taxonomic annotation of the crAss-like phages.

(B) A bar plot depicting the compositions of the subfamilies of the crAss-like phage genomes for the JVD and MGV. The genomes from the MGV are grouped according to their continental origin.

(C) A bar plot depicting the compositions of the subfamilies of the crAss-like phages calculated from the abundances (RPKM) in each group.

(D and E) Heatmaps represent the association of the crAss-like phages to the diseases (upper) and Shannon index (lower) at the subfamily (D) and genus (E) level, respectively. The colors indicate the Z score in each test. ∗p < 0.05. ∗∗p < 0.05/number of clades (per objective variables). ∗∗∗p < 0.05/number of tests across all diseases (only for association tests for diseases). See also Tables S8, S9, S10, and S11.