Figure 3.
Mobile element insertions
(A) Violin plot showing the distribution of the number of LINE insertions per sample grouped by tumor type. Black dots indicate the median values for each tumor type.
(B) Complex LINE cluster in HMF002232B, a colorectal cancer. Overlapping segments from the LINE source element from chr14:59.2M have been inserted in at least 20 independent locations scattered throughout the genome.
(C) Histogram showing frequency of breakends positions for all mobile element transductions in Hartwig cohort originating from the five most active LINE source elements relative to the last base of the LINE source element.
(D) Pseudogene insertion of GLE1 into an overlapping break junction on chromosome 5 in HMF002165A, a non-small cell lung cancer. All 16 exons of the GLE1 canonical transcript are inserted, but parts of the first and last exons are lost.
(E) Samples with high numbers of LINE insertions also have high numbers of pseudogene insertions.