Figure 4.

Forward simulations of demographic scenarios and impact on deleterious mutations

(A) Simulated demographic scenarios representing a Stable scenario as control (N_e = 10,000), a Mainland scenario (LGM bottleneck and long-term N_e = 6,000), a Stewart Island scenario (LGM decline and long-term N_e = 1,000), and an Extreme decline scenario (LGM decline and long-term N_e = 100).

(B) Additive genetic load calculated as the sum of selection coefficients for homozygous mutations plus the sum of selection coefficients multiplied by the dominance coefficients for heterozygous mutations. Black dots and whiskers show the means and 95% CIs for each demographic scenario.

See also Figures S23–S27.