Table 1. Patient demographics, disease characteristics, and conditioning regimen.
Characteristics | N (%) |
---|---|
Gender | |
Male | 38 (75) |
Female | 13 (25) |
Age (median years, range) | 44 (23 – 74) |
Diagnosis | |
ALL | 51 (100) |
Ph (+) | 15 (29) |
Ph (–) | 36 (71) |
CD19+ CAR T-cell dose | |
4×105 | 1 (2) |
1×106 | 19 (37) |
3×106 | 31 (61) |
Conditioning regimen prior to CD19+ CAR T-cell therapy | |
Cyclophosphamide 3,000 mg/m2 | 27(53) |
Cyclophosphamide 1,500 mg/m2 | 11 (21) |
Cyclophosphamide 3,000 mg/m2 + fludarabine 25 mg/m2 | 8 (16) |
Cycloposphamide 60 mg/kg + fludarabine 25 mg/m2 | 2 (4) |
Cyclophosphamide 3,000 mg/m2 + dasatinib 100 mg | 2 (4) |
Cyclophosphamide 400 mg/m2 + clofarabine 20 mg/m2 | 1 (2) |