TABLE 1.
Nucleocytoplasmic signal sequences
| Signal | Proposed consensus sequencesa | Source or reference |
|---|---|---|
| Classical monopartite NLS | B4, P(B3x), Pxx(B3x), B3(H/P) | PSORT II server |
| Classical bipartite NLS | BBx10(B3x2) | PSORT II server |
| M9 NLS | (Y/F/W)x2JxSxZG(P/K)(M/L/V)(K/R) | 24 |
| Viral NLS | RxxRRx1,2RBR | 182, 258 |
| Ribosomal L23a NLS | VHSHKKKKIRTSPTFRRPKTLRLRRQPKYRRKSAPRRNK | 105 |
| Leucine-rich NES | Lx2,3(F/I/L/V/M)x1,2,3Lx(I/V/L) | 25 |
| Unusual NESs | IxxxIxxLxT, WxKIxLxP | 54, 123 |
a
B, basic residue (K or R); J, hydrophilic residue; Z, hydrophobic residue; x, any residue; subscript numbers show number of residues; letters in parentheses can be in any order; letters separated by a slash are alternate permitted residues.