Table 6.
One-Way Sensitivity Analysis Results
| Quality-Adjusted Life Expectancy (QALYs) | Cost (SEK) | ICUR (SEK Per QALY Gained) | |||||
|---|---|---|---|---|---|---|---|
| Placebo | SQ Tree SLIT-Tablet | Δ | Placebo | SQ Tree SLIT-Tablet | Δ | ||
| Base case | 7.951 | 7.992 | +0.041 | 103,981 | 113,057 | +9077 | 223,445 |
| 0% discount rate | 9.041 | 9.087 | +0.046 | 118,233 | 123,880 | +5647 | 122,266 |
| 5% discount rate | 7.342 | 7.380 | +0.038 | 96,012 | 106,927 | +10,914 | 290,985 |
| 5 year time horizon | 4.308 | 4.330 | +0.022 | 56,338 | 80,918 | +24,580 | 1,116,840 |
| 15 year time horizon | 11.003 | 11.060 | +0.056 | 143,892 | 139,981 | −3911 | Dominant |
| No mortality | 8.083 | 8.125 | +0.041 | 105,705 | 114,402 | +8696 | 210,592 |
| Same HCP interactions in placebo arm as the SQ Tree SLIT-Tablet arm | 7.951 | 7.992 | +0.041 | 124,546 | 113,057 | −11,489 | Dominant |
| Same HCP interaction frequency in placebo and SQ Tree SLIT-Tablet arms, GP only | 7.951 | 7.992 | +0.041 | 109,911 | 113,057 | +3147 | 77,461 |
| Productivity loss based on birch pollen season | 7.951 | 7.992 | +0.041 | 64,526 | 84,955 | +20,429 | 502,920 |
| No indirect costs | 7.951 | 7.992 | +0.041 | 2550 | 43,921 | +41,371 | 1,018,468 |
| No productivity loss for HCP interactions | 7.951 | 7.992 | +0.041 | 103,981 | 112,062 | +8082 | 198,960 |
| No symptom-relieving medication costs | 7.951 | 7.992 | +0.041 | 101,430 | 111,055 | +9624 | 236,930 |
| No disease-modifying effect with SQ Tree SLIT-Tablet (10 years of SLIT) | 7.951 | 7.992 | +0.041 | 103,981 | 193,785 | +89,804 | 2,210,793 |
| No disease-modifying effect with SQ Tree SLIT-Tablet (no effects on productivity loss, absenteeism, symptom-relieving medication use, or QoL after treatment) | 7.951 | 7.965 | +0.014 | 103,981 | 135,537 | +31,557 | 2,314,583 |
| Persistence in line with Allam et al | 7.951 | 7.964 | +0.012 | 103,981 | 106,703 | +2723 | 223,445 |
Abbreviations: GP, general practitioner; HCP, healthcare professional; ICUR, incremental cost-utility ratio; SEK, 2021 Swedish Krona; QALY, quality-adjusted life year; QoL, quality of life.