Table 4.
Drug interaction of GemPac and GemErlo.
| GemPac | ||||||
|---|---|---|---|---|---|---|
| IC50 values in nM | Interaction | |||||
| Gemcitabine | GemPac (Relative to Gemcitabine) |
Paclitaxel | GemPac (Relative to Paclitaxel) |
CI value | ||
| 0.57 | 0.82 | 7.04 | 0.01 | 1.44 | Antagonism | |
| GemErlo | ||||||
| IC50 values in nM | Interaction | |||||
| Gemcitabine | GemErlo (Relative to Gemcitabine) |
Erlotinib | GemErlo (Relative to Erlotinib) |
CI value | ||
| 0.57 | 0.87 | 652 | 0.18 | 1.53 | Antagonism | |
IC50 values are given for the single drugs and for the GemPac and GemErlo combinations, respectively in nM. The IC50 values of GemPac and GemErlo are given as relative to the corresponding single drug, based on the molar ratios (2.6). The combination index (CI) and the resulting conclusion of antagonism between the components of the regimen are also given.