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. 2023 Feb 7:1–15. Online ahead of print. doi: 10.1038/s41577-023-00837-1

Fig. 1. General structure of the TREM molecules.

Fig. 1

A three-dimensional model of the structure of the triggering receptors expressed on myeloid cells (TREMs), based on the three-dimensional TREM2 structure predicted by AlphaFold219. The extracellular region of the TREMs consists of an IgV fold on a long stalk. The N terminus leader sequence and the C terminus transmembrane and cytoplasmic domains are also depicted.