Fig. 1. General structure of the TREM molecules.
A three-dimensional model of the structure of the triggering receptors expressed on myeloid cells (TREMs), based on the three-dimensional TREM2 structure predicted by AlphaFold219. The extracellular region of the TREMs consists of an IgV fold on a long stalk. The N terminus leader sequence and the C terminus transmembrane and cytoplasmic domains are also depicted.