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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Exp Neurol. 2023 Jan 7;361:114320. doi: 10.1016/j.expneurol.2023.114320

Fig. 2: Expression of cannabinoid and non-cannabinoid receptors in the CP and cortex in the post-traumatic mouse brain.

Fig. 2:

A-D) Fixed frozen mouse brain sections were analyzed by immunohistochemical analysis. Brains were stained for cannabinoid receptors (CB1 and CB2) and non-cannabinoid receptor TRPV1, and were analyzed for their expression up to 26 days post-TBI. CB1, CB2 and TRPV1 showed higher expressions at 3 days and returned to a reduced level at day 26 post-injury (B-D). (E-G) CB2 and TRPV1 showed acute upregulation at day 3 and returned to basal levels at day 26 post-TBI. However, CB1 was found to be high at day 3, but showed significantly increased expression in cortex at day 26 post-TBI (H). Groups were compared by Two-Way ANOVA analysis with Tukey’s post-hoc comparison. Results were calculated as mean fluorescent intensity (MFI) ± SEM. (n=5; ns= not significant; ***p<0.001; ****p<0.0001 vs. sham; Scale bar 125μm).