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. 2023 Feb 3;15:101–119. doi: 10.2147/BCTT.S387793

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© 2023 Zhang et al.

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Characterization and detection of HFON and DOX@HFON: (A) SEM images of HFON and the inserted picture is HFON cross section SEM image; (B and C) DLS and Zeta detection results of HFON and HFON loaded with DOX; (D) EDS spectrum and quantitative analysis results of DOX@HFON; (E) XPS spectrum of DOX@HFON; (F) Mapping result of DOX@HFON, including Fe, O, N and C element; (G) ESR detection of HFON and DOX@HFON: ability to generate • OH; (H) Standard curve of DOX@HFON; (I) T2 relaxation rate of DOX@HFON, and T2-weighted images under different iron concentrations (mM); (J) The hysteresis curve of DOX@HFON. (K) DOX@HFON release curve in vitro; (L) Stability detection of DOX@HFON in PBS and 10% FBS.