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. 2023 Feb 5;15(1):2174407. doi: 10.1080/19490976.2023.2174407

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — SFB’s inhibition of mRV infection requires RAR signaling. Conventional C57BL6 mice were orally administered PBS or SFB 7 days before rotavirus inoculation. RAR inhibitor (RARi BSM493, 400ug) or vehicle (10% DMSO in corn oil) was given orally to mice every other day (q.o.d) for 7 days pre- and post-inoculation. (a) Experiment approach. (b) ELISA measure of fecal rotavirus shedding levels over time, normalized to sample weight. (c) Areas under the curve analysis of (b). (d) ELISA measure of rotavirus-specific antibodies in serum and fecal samples. Results are mean ± SD. Data represent two independent experiments with four to five mice per group that yielded similar results. ** p < .01. **** p < .0001. ns, not significant.