Kidney cortex samples from male and female mice 3 days following a single intraperitoneal injection of saline (vehicle) or 15 mg/kg cisplatin. Real-time quantitative PCR of various endothelin (Edn) related genes from these cortex samples. (A) Edn1, (B) Edn3, (C) Ece1, (D) Ednra, and (E) Ednrb. All values are relative to the male saline group. P values from a two-factor ANOVA reported and results of Tukey’s post hoc are represented by lines with the p value reported. Sample sizes: male saline = 6, male cisplatin = 6, female saline n = 6, and female cisplatin = 5.