. Author manuscript; available in PMC: 2023 May 1.

Published in final edited form as: Leukemia. 2022 Sep 20;36(11):2669–2677. doi: 10.1038/s41375-022-01704-z

Table 1.

Baseline characteristics according to DLIx (as continuous variable)

Total (N=171)	Number (%)	Median DLIx (10⁹/L)	p-uni	OR [95%CI]	p-multi
DLBCL/HGBCL	133 (78)	0.51	0.76	-	-
PMBCL/TFL	38 (22)	0.58
Age > 60 years	78 (46)	0.55	0.72	-	-
<= 60 years	93 (54)	0.51
Male	120 (70)	0.49	0.25	-	-
Female	51 (30)	0.62
ECOG PS 2–4	20 (12)	0.32	0.76	-	-
0–1	151 (88)	0.58
Ann Arbor Stage III-IV	140 (82)	0.51	0.91	-	-
Stage I-II	31 (18)	0.55
Extra-nodal sites > 1	109 (64)	0.47	0.20	-	-
0–1	62 (36)	0.63
IPI score 3–5	96 (56)	0.44	0.41	-	-
0–2	75 (44)	0.60
ANC low	35 (20)	0.47	0.52	-	-
normal	136 (80)	0.56
AMC low	11 (6)	0.50	0.95	-	-
normal	160 (94)	0.52
ALC low	131 (77)	0.82	<0.001	0.03	1
normal	40 (23)	1.4		[0.01–1.1]
Hemoglobin low	163 (95)	0.51	0.68	-	-
normal	8 (5)	0.90
PLT count low	88 (51)	0.40	0.003	0.7	0.27
high	83 (49)	0.69		[0.3–1.3]
CRP high	113 (66)	0.46	0.11	-	-
normal	58 (34)	0.68
Ferritin high	126 (74)	0.47	0.24	-	-
normal	45 (26)	0.61
LDH high	118 (69)	0.45	0.14	-	-
normal	53 (31)	0.61
eGFR low	31 (18)	0.55	0.91	-	-
high	140 (82)	0.52
Previous therapies > 2	135 (79)	0.48	0.29	-	-
2	36 (21)	0.61
Bridging therapy: yes	86 (50)	0.49	0.02	0.4	0.007
no	85 (50)	0.60		[0.2–0.8]
Bridging: chemotherapy	52 (30)	0.41	0.18	-	-
other/no	119 (70)	0.57
Refractory disease: yes	134 (78)	0.52	0.90	-	-
no	37 (22)	0.55
Previous auto-SCT: yes	45 (26)	0.55	0.89	-	-
no	126 (74)	0.51
Previous allo-SCT: yes	3 (2)	0.88	0.98	-	-
no	168 (98)	0.55

DLIx, delta lymphocyte index; OR, odds ratio; CI, confidence interval; uni, univariate; multi, multivariate; DLBCL, diffuse large B-cell lymphoma; HGBCL, high grade B-cell lymphoma; PMBCL, primary mediastinal B-cell lymphoma; TFL, transformed follicular lymphoma; ECOG, European Cooperative Oncology Group; PS, performance status; IPI, international prognostic index; ANC, absolute neutrophil count; AMC, absolute monocyte count; ALC, absolute lymphocyte count; PLT, platelet; CRP, C-reactive protein; LDH, lactate dehydrogenase; eGFR, estimated glomerular filtration rate; auto, autologous; allo, allogeneic; SCT, stem cell transplant