Table 2.
Baseline characteristics according to DLIx (as categorical variable)
| Total (N=171) | High DLIx (N=126) |
Low DLIx (N=45) |
p-uni | OR [95%CI] | p-multi |
|---|---|---|---|---|---|
| DLBCL/HGBCL | 101 (80) | 32 (71) | 0.22 | - | - |
| Age > 60 years | 59 (47) | 19 (42) | 0.61 | - | - |
| Male | 90 (71) | 30 (67) | 0.57 | - | - |
| ECOG PS 2–4 | 11 (9) | 9 (20) | 0.06 | - | - |
| Ann Arbor Stage III-IV | 102 (81) | 38 (84) | 0.66 | - | - |
| Extra-nodal sites > 1 | 75 (60) | 34 (76) | 0.07 | - | - |
| IPI score 3–5 | 62 (49) | 34 (76) | 0.003 | 0.7 [0.2–1.8] | 0.42 |
| ANC low | 23 (18) | 12 (27) | 0.28 | - | - |
| AMC low | 6 (5) | 5 (11) | 0.16 | - | - |
| ALC low | 86 (68) | 45 (100) | <0.001 | 0.03 [0.01–1.1] | 1 |
| Hemoglobin low | 119 (94) | 44 (98) | 0.68 | - | - |
| PLT count low | 59 (47) | 29 (64) | 0.06 | - | - |
| CRP high | 80 (63) | 33 (73) | 0.27 | - | - |
| Ferritin high | 91 (72) | 35 (78) | 0.56 | - | - |
| LDH high | 78 (62) | 40 (89) | 0.10 | - | - |
| eGFR low | 22 (17) | 9 (20) | 0.82 | - | - |
| Previous therapies > 2 | 98 (78) | 37 (82) | 0.67 | - | - |
| Bridging therapy: yes | 56 (44) | 30 (67) | 0.02 | 0.5 [0.2–0.9] | 0.04 |
| Bridging: chemotherapy | 35 (28) | 17 (38) | 0.26 | - | - |
| Refractory disease: yes | 98 (78) | 36 (80) | 0.84 | - | - |
| Previous auto-SCT: yes | 38 (30) | 7 (16) | 0.08 | - | - |
| Previous allo-SCT: yes | 3 (2) | 0 (0) | 0.57 | - | - |
DLIx, delta lymphocyte index; OR, odds ratio; CI, confidence interval; uni, univariate; multi, multivariate; DLBCL, diffuse large B-cell lymphoma; HGBCL, high grade B-cell lymphoma; PMBCL, primary mediastinal B-cell lymphoma; TFL, transformed follicular lymphoma; ECOG, European Cooperative Oncology Group; PS, performance status; IPI, international prognostic index; ANC, absolute neutrophil count; AMC, absolute monocyte count; ALC, absolute lymphocyte count; PLT, platelet; CRP, C-reactive protein; LDH, lactate dehydrogenase; eGFR, estimated glomerular filtration rate; auto, autologous; allo, allogeneic; SCT, stem cell transplant