Figure 4. Trials assessing the treatment of ISR.

The size of the circles corresponds to the size of the trial. The colour of the circles’ perimeter indicates the underlying stent type in the ISR population studied. The inner colour of the circle indicates the interventional strategies used in the trial, corresponding to the coloured bars at the top of the figure. The length of the coloured bars at the top of the figure indicates the time span during which each therapeutic modality has been studied for the treatment of ISR. Detailed descriptions of the studies and the randomised arms are provided in Supplementary Table 1. BMS: bare metal stent; DES: drug-eluting stent; ISR: in-stent restenosis