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. 2022 Jun 3;18(2):e103–e123. doi: 10.4244/EIJ-D-21-01034

Figure 5. Clinical outcomes in major ISR trials.

Figure 5

ISR trials with over 200 patients enrolled are divided into 5 research themes: intravascular brachytherapy trials, rotational atherectomy trials, DES trials, DCB trials, and DES vs DCB trials. MACE is the outcome of interest displayed for each trial. Three ISR trials with >200 patients enrolled are not shown in this figure: These are RIBS I (Bare Metal Stent vs Balloon Angioplasty), RESCUT (Balloon Angioplasty vs Cutting Balloon) and OSIRIS (Placebo vs Normal Dose Sirolimus vs High Dose Sirolimus). Details of all ISR trials identified in our search are provided in Supplementary Table 1 and Supplementary Table 2. BA: balloon angioplasty; DCB: drug-coated balloons; DES: drug-eluting stent; DES-E: everolimus-eluting stent; DES-P: paclitaxel-eluting stent; DES-S: sirolimus-eluting stent; DES-Z: zotarolimus-eluting stent; ISR: in-stent restenosis; IVBT: intravascular brachytherapy; MACE: major adverse cardiac events; NSB: non-slip balloon: SB:scoring balloon; UHPNCB: ultra-high-pressure non-compliant balloon