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. 2023 Jan 26;19(1):e1011131. doi: 10.1371/journal.ppat.1011131

Fig 1. Characterization of RG4s in SARS-CoV-2 host factors.

Fig 1

(A) RG4 potential of SARS-CoV-2 host factor mRNAs. Prediction results are shown with multi-parameter analysis of G-sore, G4H and G4NN. (B) Graphical representations of RG4 sequence conservation of PQSs in Ace2, Axl and Furin. The sequences were retrieved from the National Center for Biotechnology Information (NCBI) and aligned using WebLogo software. (C-H) CD spectrum for indicated PQSs of Ace2 (C), Axl (D), Dpp4 (E), Furin (F), Golga7 (G), and Zdhhc5 (H) under KCl or LiCl conditions. (I-K) CD spectrum (I), ThT (J) and NMM (K) fluorescence emission spectra for wild-type (WT) or mutated (MUT) of Ace2 PQS-2302 (first panel), Axl PQS-91 (second panel), and Furin PQS-1234 (third panel) and PQS-1276 (fourth panel) under KCl conditions.