Table 4. Risk of bias of included non-randomized interventional studies.

Author, year	ROBINS-I Assessment Domains
	Confounding	Selection of patients into the study	Classification of interventions	Deviations form intended interventions	Missing data	Measurement of outcomes	Selection of the reported result	Total risk of bias
Gardiner, [33] 2013	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Kakarala, [34] 2018	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
McKimm, [36] 2018	No information	Serious risk	Low risk	Low risk	No information	Moderate risk	Moderate risk	Serious risk
Palamara, [37] 2015	Serious risk	Moderate risk	Low risk	Low risk	No information	Moderate risk	Moderate risk	Serious risk
Palamara, [38] 2018	Moderate risk	Moderate risk	Moderate risk	Moderate risk	No information	Moderate risk	Moderate risk	Serious risk
Palamara, [39] 2021	Moderate risk	Moderate risk	Moderate risk	Moderate risk	No information	Low risk	Low risk	Moderate risk
Solms, [41] 2021	Moderate risk	Moderate risk	Low risk	Low risk	No information	Low risk	Low risk	Moderate risk
Song, [42] 2020	Moderate risk	Moderate risk	Moderate risk	Moderate risk	Moderate risk	Moderate risk	Moderate risk	Serious risk