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. 2023 Jan 11;12:e79363. doi: 10.7554/eLife.79363

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© 2023, Ainciburu, Ezponda et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Author response image 4. — (A) UMAP visualization of HSC from young (left) and elderly (right) donors subjected to re-integration and unsupervised clustering.

Cells are colored by clusters. (B) Bar plot showing the proportion of cells from each donor assigned to the different clusters. (C) UMAP plots for young (left) and elderly (right) HSC colored by the normalized expression of CDK6 (top left) and by the summarized expression of multiple gene signatures, quantified as scores calculated using the software AUCell.