TABLE 1.
Gene set enrichment summary of biological processes most associated with RBM3‐bound mRNA.
| Summary description | Gene set description(s) | Gene | E‐score |
|---|---|---|---|
| “Proteosome Complex” | “Proteosome accessory complex”; “Proteosome complex”; “Proteosome regulatory particle”; “Peptidase complex”; “Endopeptidase complex”; “Proteosome regulatory particle, base subcomplex” | Psmd11 | 3.35 |
| Psmd3 | 3.17 | ||
| Rad23b | 6.56 | ||
| Ubqln4 | 5.54 | ||
| Adrm1 | 3.00 | ||
| Psma3 | 5.93 | ||
| Psmd7 | 7.50 | ||
| Psma6 | 4.82 | ||
| Ubr4 | 4.76 | ||
| “Translation Initiation” | “Translation Regulator Activity, Nucleic Acid Binding”; “Translation Initiation Factor Activity”; “Translation Factor Activity, RNA Binding” | Eif3l | 3.29 |
| Eif4e2 | 7.55 | ||
| Eif4b | 5.03 | ||
| Eif3d | 4.76 | ||
| Gfm1 | 4.76 | ||
| Eif2b1 | 4.63 | ||
| Eif1ax | 4.36 | ||
| Gstp1 | 3.45 | ||
| Eif2s2 | 4.19 | ||
| Eif3f | 4.14 | ||
| Larp1 | 4.10 | ||
| “Eukaryotic Translation Initiation Factor 2B Complex” | Eif2b1 | 4.63 | |
| Eif2b5 | 3.36 | ||
| Eif2b2 | 4.07 | ||
| “Contractile Apparatus” | “Actin Cytoskeleton”; “Myofilament”; “Striated Muscle Thin Filament”; “Z Disc”; “Muscle Myosin Complex”; “M Band”; “Sarcomere”; “Contractile Fiber”; “Myofibril”; “A Band” | Flnc | 4.76 |
| Myl1 | 4.43 | ||
| Vps11 | 3.52 | ||
| S100a1 | 4.36 | ||
| Myl6 | 4.73 | ||
| Actn4 | 7.01 | ||
| Itgb1bp2 | 6.71 | ||
| Actn2 | 5.98 | ||
| Myom1 | 5.93 | ||
| Myom2 | 5.43 | ||
| Trip6 | 5.53 | ||
| Myl4 | 7.86 | ||
| Dnaja3 | 4.85 | ||
| Ttn | 5.26 | ||
| Trim63 | 5.84 | ||
| Tnnt2 | 7.81 | ||
| Tpm1 | 4.60 | ||
| Dhx9 | 5.14 | ||
| Fbxl22 | 4.36 |
Note: Gene set descriptions represent individual gene ontology terms. E‐score represents enrichment of genes in the immunoprecipitated group relative to the input control. Genes highlighted in bold indicate greater than fivefold enrichment (q < 0.01). N = 3 technical replicates per condition (IP or IgG control).