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. 2023 Feb 7;14(2):88. doi: 10.1038/s41419-023-05595-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A, B PINK1 knockdown by shRNA had no significant effect on the expression of cleaved PARP, BAX, cleaved Caspase-3, or cytochrome c in MC3T3-E1 cells. C, D Flow cytometry results showed that PINK1 knockdown further increased the cell apoptotic rate when stimulated with AOPPs, and the application of rapamycin did not reverse this trend. E–I Rapamycin failed to inhibit the upregulation of cleaved PARP, BAX and cytochrome c in AOPP-stimulated shPINK1 MC3T3-E1 cells. All experiments were repeated for at least three times. Data are presented as the mean ± SD. *^#†P < 0.05 between connected groups. Clvd PARP cleaved PARP; Clvd Cas-3 cleaved Caspase-3; Cyt-C cytochrome c.