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. 2023 Feb 7;14(2):88. doi: 10.1038/s41419-023-05595-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A, B Western blot results of the tibia bone tissue showed that rapamycin significantly decreased the AOPP-induced upregulation of cleaved PARP, BAX, cleaved Caspase-3, and cytochrome c. C TUNEL assay results showed that rapamycin significantly inhibited AOPP-induced osteoblast apoptosis in vivo (scale bar = 50 μm). D Immunohistochemical results showed that rapamycin inhibited the AOPP-induced expression of BAX and cleaved Caspase-3 in osteoblasts in vivo (scale bar = 50 μm). Data are presented as the mean ± SD, *P < 0.05 versus control, ^#P < 0.05 versus AOPPs, n = 8. Clvd PARP cleaved PARP; Clvd Cas-3 cleaved Caspase-3; Cyt-C cytochrome c.