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. 2023 Feb 7;14(2):87. doi: 10.1038/s41419-023-05625-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Venn diagram showing the numbers of overlapping TFs among the peroxisomal FAO rate-limiting enzyme genes. b Correlation between the expression levels of VDR and ACOX1, EHHADH, ACAA1, SCP2, ACOX3 in 41 normal (orange) and 471 tumor (green) COAD samples, as determined by Pearson’s r analysis. c Protein expression of ACOX1, EHHADH, ACAA1, SCP2, ACOX3, and ABCD4 in HCT116 cells with VDR inhibition. d Western blot analysis of ACOX1, EHHADH, ACAA1, SCP2, ACOX3 and ABCD4 expression in HCT116 p53^+/+ or p53^−/−cells expressing VDR. e Dual-luciferase assays in HEK293T cells transfected with the indicated plasmids or treated with Nutlin3 (10 μΜ), n = 3. f qPCR ChIP analyses of VDR binding to ACOX1, EHHADH, ACAA1, and SCP2 promoter regions in HCT116 p53^+/+ or p53^−/−cells, n = 3. Data were presented as mean ± SD. **P < 0.01, ***P < 0.001.