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. 2023 Feb 7;14(2):87. doi: 10.1038/s41419-023-05625-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a A Scheme for the AOM/DSS-induced colon cancer model in Trp53^fl/fl and VP mice (top). Each mouse received two intraperitoneal injections of the indicated virus during the second processing of DSS treatment. Typical images of colon tumors expressing the indicated ATIC proteins 98 days after AOM/DSS treatment. b ATIC immunohistochemistry (IHC) in representative sections of tumor tissues from a. Scale bar, 20 μm. c Colon tumor numbers in mice from a, n = 6. d ATIC activity and ATP levels were measured in tumor tissues from a, n = 6. e Relative purine nucleotide levels were analyzed by LC-MS/MS in CRC tumors from Trp53^fl/fl and VP mice and normalized to per mg tumor tissue, n = 3. f–h HCT116 cells with stable expression the indicated vectors were injected subcutaneously into BALB/c nude mice, n = 6. Tumor size was measured every 3 days f. Tumors were dissected and photographed (g) and weighed on day 18 (h). i Western blot analysis of ATIC acetylation in tumor tissues from each group, as in f, n = 3. j ATIC activity was measured in tumor tissues from f, n = 6. Data were presented as mean ± SD.