TABLE 5.
Contributions of rhCYPs to EA or EB metabolism assessed by the TNR approach (n = 3).
| Compound | CYPs | Metabolic rate/pmol·min−1/(pmol rhCYP) | Mean CYP content/pmol·mg−1 (protein) | Normalized metabolic rate/pmol·mg−1·min−1 (protein) | TNR relative contribution (%) |
|---|---|---|---|---|---|
| EA | 1A2 | 0.96 | 45 | 43.00 | 8.48 |
| 2C9 | 1.05 | 96 | 100.74 | 19.87 | |
| 2C19 | 0.93 | 19 | 17.76 | 3.50 | |
| 2D6 | 0.98 | 10 | 9.82 | 1.94 | |
| 3A4 | 3.11 | 108 | 335.60 | 66.20 | |
| EB | 1A2 | 1.46 | 45 | 65.71 | 11.62 |
| 2C9 | 1.39 | 96 | 133.69 | 23.65 | |
| 2C19 | 1.31 | 19 | 24.81 | 4.39 | |
| 2D6 | 1.22 | 10 | 12.17 | 2.15 | |
| 3A4 | 3.05 | 108 | 328.89 | 58.18 |