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. 2023 Jan 25;16:1098343. doi: 10.3389/fnbeh.2022.1098343

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Copyright © 2023 Landin and Chandler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Freezing behavior and lever pressing assessed on the test day of the platform-mediated avoidance task. (A) When freezing to the tone on the test day was examined irrespective of location, female rats exhibited higher levels of freezing compared to the male rats. AIE exposure did not significantly alter freezing in either sex. (B) When analysis of freezing to the tone was restricted to when the rats were positioned on the platform, the sex difference in freezing was no longer observed. (C) Examination of lever responding during the test session revealed total lever pressing by AIE-exposed male rats was significantly reduced. (D) No lever pressing during the tone was observed. Data represent the means ± sem (n = 12–13/group). ^*indicates significant main effect of sex, p = 0.02; ^@indicates significant difference from the male Air rats, p = 0.010; ^%indicates significant main effect of AIE, p = 0.010.