Figure 6.

Active avoidance behavior assessed on the last day of extinction of the platform-mediated avoidance task. (A) When the percentage of time the rats were located on the platform was examined over the entire extinction session, male AIE-exposed rats exhibited significant increases in time on the platform compared to the male Air rats. (B) When analysis of time on the platform was restricted to the period of the tones, the female rats continued to spend significantly more time on the platform. (C) Chi-square analysis also revealed there was a significant difference in the percentage of rats considered to have remained on the platform during the 2-s shock interval (SI). Analysis of the time-course in 3 s bins of when the male (D) and female (E) rats were located on the platform during the tone presentations revealed a significant main effect of time in the female rats. Data represent the means ± sem (except for the contingency date in panel C; n = 12–13/group). ^*indicates significant difference between Air and AIE, p = 0.028; ^@indicates significant difference between the male Air and male AIE rats, p = 0.018; ^#indicates significant difference between male and female rats, p = 0.000; ^&indicates significant group difference, p = 0.000.