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. 2023 Jan 25;11:1123975. doi: 10.3389/fcell.2023.1123975

FIGURE 3.

FIGURE 3

Examples of circRNA-mediated epigenetic regulation of gene expression (A) In hepatocellular carcinoma (HCC), the upregulated circLRIG3 acts as a scaffold to promote the interaction between EZH2 and its substrate, STAT3. Methylated and, subsequently, phosphorylated STAT3 induces the expression of oncogenic gene targets. (B) In breast cancer, FECR1 simultaneously recruits TET1 (in cis) and represses DNMT1 (in trans) to decrease the methylation levels of the oncogene Friend leukemia virus integration 1 (FLI1). (C) circRNA DONSON, overexpressed in gastric cancer, modulates the levels of BMI1 by sponging miR-802 in the cytoplasm while inducing the nuclear expression of SOX4 by directly recruiting NURF on its promoter. (D) circAGFG1 and circ0019435 are both overexpressed in cervical cancer and induce the EZH2-mediated silencing of oncosuppressors p53 and PTEN, and DKK1, respectively. (E) circKcnt2 is overexpressed upon intestinal inflammation and mitigates the inflammatory response through the recruitment of NuRD complex on the promoter of the pro-inflammatory molecule BATF.