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. 2021 Dec 5;79(1):223–234. doi: 10.1007/s13105-021-00857-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Chemotherapeutic pulsing with gemcitabine and paclitaxel to mimic clinical dosing in vitro. (A and C) The graphs show the cell viability of pancreatic cancer cell lines after a pulse with gemcitabine (A) or paclitaxel (C) representing 0.5 cMAX or 0.1 cMAX, data was analysed using DMSO as a control set to 100%. (B and D) The graphs show the cell viability of CAFs after a pulse with gemcitabine (B) or paclitaxel (D) representing 0.5 cMAX or 0.1 cMAX. At 24, 48, 72 and 96 h cell viability was determined using CellTiter-Glo. The data are shown as ± SEM of at least 2 independent experiments performed in triplicate and normalised to a DMSO control set to 100%. P value determined by one-way ANOVA with post hoc Dunnett’s test. The * symbol refers to the 0.5 cMAX condition with *P ≤ 0.05 and **0.01. The Φ symbol refers to the 0.1 cMAX condition with Φ P ≤ 0.05