Table 2.
Panel A: agreement between manual segmentation (considered gold standard) and volume measurement by qER–NCCT for all ICH (left column) and for IVH only (right column). Panel B: agreement between manual segmentation (considered gold standard) and volume measurement by qER–NCCT (left column), the ABC/2 method and qER–NCCT (middle column), and manual segmentation, and the ABC/2 method (right column) for ICH without IVH extension. Panel C: agreement between manual segmentation (considered gold standard) and volume measurement by qER–NCCT, depending on ICH size and attenuation.
| Panel A: agreement for all ICH and IVH only | ||||
| Manual segmentation vs. qER–NCCT | ||||
| Agreement statistics | Manual vs. qER–NCCT | Manual vs. qER–NCCT | ||
| n = 1581 (all ICH) | n = 44 (IVH only) | |||
| Mean difference (ml) | 8.3 | 9.0 | ||
| Standard deviation (ml) | 12.1 | 11.0 | ||
| Median difference (ml) | 4.0 | 6.0 | ||
| IQR (ml) | 10.0 | 9.0 | ||
| 95% LoA (ml, low–high) | − 15.0__32.0 | − 12.0__30.6 | ||
| ICC | 0.96 | 0.95 | ||
| 95% CI | (0.88–0.98) | (0.77–0.98) | ||
| Panel B: agreement for ICH without IVH extension | ||||
| Manual segmentation vs. qER–NCCT, ABC/2 vs qER–NCCT and ABC/2 vs. Manual segmentation | ||||
| Agreement statistics | Manual vs. qER–NCCT | ABC/2 vs. qER–NCCT | ABC/2 vs. Manual | |
| n = 836 | n = 836 | n = 891 | ||
| Mean difference (ml) | 4.5 | 5.9 | 1.3 | |
| Standard deviation (ml) | 8.5 | 12.8 | 7.1 | |
| Median difference (ml) | 2.0 | 1.5 | -0.1 | |
| IQR (ml) | 5.0 | 5.9 | 1.8 | |
| 95% LoA (ml, low–high) | − 15.0__32.0 | − 12.0__30.6 | − 12.7__15.3 | |
| ICC | 0.92 | 0.86 | 0.97 | |
| 95% CI | (0.84–0.95) | (0.78–0.90) | (0.97–0.98) | |
| Panel C: agreement depending on size and heterogenicity for all ICH | ||||
| Manual segmentation vs. qER–NCCT | ||||
| Agreement statistics | Number of patients | Mean difference | ICC (95% CI: upper, lower) | |
| ICH volume < 10 ml | 603 | 1.0 | 0.90 (0.60–0.95) | |
| ICH volume (10–30 ml) | 398 | 4.9 | 0.70 (− 0.17–0.9) | |
| ICH volume (30–60 ml) | 269 | 11.0 | 0.55 (− 0.22–0–81) | |
| ICH volume (60–100 ml) | 183 | 20.0 | 0.45 (− 0.21–0.75) | |
| ICH volume > 100 ml | 127 | 30.3 | 0.75 (− 0.15–0.91) | |
| Homogenous ICH | 1198 | 5.5 | 0.97 (0.92–0.99) | |
| Heterogenous ICH | 382 | 17.2 | 0.92 (0.53–0.97) | |
ICH Intracerebral hemorrhage, IVH Intraventricular hemorrhage, IQR Interquartile range, LoA Limits of agreement, ICC Interclass correlation, CI Confidence interval