Table II.

Biological response to prolonged methylprednisolone treatment

Biological response to prolonged methylprednisolone treatment
Plasma and bronchoalveolar lavage findings
TNF-α, IL-1β, IL-6 [10], [11], [12], [13]	Decreased
C-reactive protein [31], [70], [72]
IL-8, soluble intercellular adhesion molecule-1 [32]	Decreased
IL-10 and IL-10/ IL-1β IL-10/TNF-α [68]	Increased
BAL total protein, albumin, neutrophilia [74], [75]	Decreased
Procollagen type I and III [35]	Decreased
Ex vivo cellular findings [56]
GRα binding to NF-κB [56]	Increased
GRα binding to GRE DNA [56]	Increased
Inhibitory protein IκBα [56]	Increased
IL-10 mRNA [56]	Increased
NF-κB κb-binding [56]	Decreased
TNF-α and IL-1β mRNA [56]	Decreased

Reproduced with permission from reference [4]