. Author manuscript; available in PMC: 2024 Apr 1.

Published in final edited form as: Mol Aspects Med. 2022 Aug 18;90:101117. doi: 10.1016/j.mam.2022.101117

Table 2.

Human-unique expression patterns of Siglec proteins

Siglec protein	Humans	Great apes	Relevant disease	Ref
CD33	High expression in microglia	Low expression in microglia (chimpanzee)	Alzheimer’s disease	(Schwarz et al., 2016)
Siglec-5	No/low expression in T lymphocytes	High expression in T lymphocytes	AIDS	(Nguyen et al., 2006; Soto et al., 2013; Soto et al., 2010)
Siglec-5, Siglec-14	Expressed in amniotic epithelium	Not expressed in amniotic epithelium (chimpanzee)	Intrauterine infection with Group B Streptococcus	(Ali et al., 2014)
Siglec-6	Expressed in placental trophoblast	Not expressed in placental trophoblast (chimpanzee, gorilla, orangutan)	Preeclampsia	(Brinkman-Van der Linden et al., 2007)
Siglec-7	Expressed in pancreatic islet cells	Not expressed in pancreatic islet cells (chimpanzee)	Type I diabetes	(Khan et al., 2020a)
Siglec-11, Siglec-16	Expressed in brain microglia	Not expressed in brain microglia (chimpanzee, orangutan)	E.coli K1 meningitis in neonates and infants	(Hayakawa et al., 2005; Schwarz et al., 2017; Wang et al., 2012a)
Siglec-11, Siglec-16	Decreased expression in ovarian fibroblasts	Strong expression in ovarian fibroblasts (chimpanzee)	Unknown	(Wang et al., 2011)