Skip to main content
. Author manuscript; available in PMC: 2023 Feb 8.
Published in final edited form as: J Alzheimers Dis. 2023;91(3):977–987. doi: 10.3233/JAD-220680

Table 1.

six independent-effect single nucleotide polymorphisms (SNPs) associated with Alzheimer’s disease (AD) progression in both Alzheimer’s Disease Neuroimaging Initiative (ADNI) and National Alzheimer’s Coordinating Center (NACC) studies

ADNI NACC
SNP/PRS Gene Chr Position (hg19) A11 A21 Beta2,3 p3 BFDP Beta2,3 p3 BFDP
rs2096224 TP73 1 3645844 G A 0.300 0.001 0.32 0.142 0.012 0.64
rs173703 PIK3R1 5 67547326 G A 0.239 0.035 0.80 0.142 0.015 0.66
rs13167294 PIK3R1 5 67555580 A C −0.202 0.031 0.77 −0.117 0.038 0.78
rs8006462 CALM1 14 90878676 C T 0.197 0.028 0.76 0.138 0.009 0.59
rs4369658 PLCG2 16 81943393 C T 0.183 0.036 0.78 0.112 0.026 0.74
rs4073828 PLCG2 16 81970495 A G −0.182 0.029 0.75 −0.177 <0.01 0.13
PRS 0.343 2.50E–08 0.200 5.69E–09
1

A1 = effect allele, A2 = reference allele.

2

Beta is log (HR).

3

Adjusted for age, sex, years of education, race, the top 3 PCs, the copy numbers of APOE E2, and E4.