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. Author manuscript; available in PMC: 2023 Feb 8.
Published in final edited form as: J Alzheimers Dis. 2023;91(3):977–987. doi: 10.3233/JAD-220680

Table 3.

Association results of PRS and different markers in ADNI dataset

Phenotype ADNI-PRS
#Subjects #Observations beta1 se1 p 1
Cognitive assessments
 CDR-SB 767 3,960 0.050 0.032 0.115
 ADAS11 767 3,988 0.492 0.152 0.001
 ADAS13 767 3,966 0.826 0.226 <0.001
 ADASQ4 767 3,993 0.333 0.084 <0.001
 MMSE 767 3,993 −0.149 0.063 0.018
 MOCA 513 2,403 −0.144 0.124 0.245
 FAQ 767 3,956 0.204 0.134 0.127
CSF biomarkers
 ABETA2 543 960 −0.034 0.018 0.059
 tau2 543 958 0.042 0.019 0.028
 Ptau1812 543 959 0.036 0.017 0.034
Imaging biomarkers
 Ventricles3 738 2,916 <0.001 0.039 0.981
 Hippocampus3 723 2,624 −0.010 0.003 <0.001
 Entorhinal3 705 2,510 −0.005 0.002 0.008
 Fusiform3 705 2,510 −0.003 0.006 0.593
 MidTemp3 705 2,510 −0.018 0.006 0.005
1

Adjusted for age at baseline, sex, years of education, race, top three PCs, and the allele copies of APOE E4 and APOE E2.

2

Log-transformed.

3

These dependent variables were expressed as the percentages to intracranial volume.